Simon Gilroy

GLARE applies representation learning to spaceflight transcriptomics, confirming existing findings and uncovering new gene expression patterns in Arabidopsis under spaceflight conditions.

This paper identifies a mutation in Arabidopsis thaliana ACT7 that confers resistance to latrunculin B by altering the nucleotide-binding cleft of the actin protein.

The paper describes a standardized RNA-Seq pipeline for spaceflight data, enabling reproducible analysis of gene expression changes in astronauts and organisms exposed to spaceflight.