The paper uses joint QTL mapping to analyze pleiotropy patterns across structured environments in budding yeast, revealing genetic interactions influenced by environmental relationships.

bioRxiv · Oct 31, 2026 · PreprintEvolutionary Biology

Laboratory yeast crosses reveal limited epistasis in the genetic basis of complex traits

Misha Gupta, Caroline M. Holmes, Jenya Belousova, Shreyas Gopalakrishnan, Artur Rego‐Costa, Michael M. Desai

The paper uses a broad range of yeast genotypes to assess epistasis in complex traits, finding limited contributions of epistasis to phenotypic variance.

bioRxiv · Apr 6, 2026 · PreprintGenetics

Parallel but distinct adaptive routes in the budding and fission yeasts after 10,000 generations of experimental evolution

Arnaud N’Guessan, Vivian Wang, Christopher W. Bakerlee, Jenya Belousova, Greta Brenna, Megan E. Dillingham, Thomas Dupic, Shreyas Gopalakrishnan, Juhee Goyal, Misha Gupta, Caroline Holmes, Parris T. Humphrey, Tanush Jagdish, Elizabeth R. Jerison, Milo S. Johnson, , Alex N. Nguyen Ba

This study compares adaptive routes in two yeast species after 10,000 generations, finding parallel but distinct molecular mechanisms of adaptation.

Nature Ecology & Evolution · Mar 13, 2026Peer-reviewedEvolutionary Biology

DYNAMICS OF CONTAMINANT MICROBES IN BIOETHANOL PRODUCTION FROM SUGARCANE

Ana L.R. Romano, Natalia Coutouné, Artur Rego‐Costa, Michael M. Desai, Marcelo Falsarella Carazzolle, Andreas Karoly Gombert

The paper investigates microbial contaminants in sugarcane bioethanol production, finding dynamic bacterial communities affect ethanol yield and yeast viability.

Journal of Industrial Microbiology & Biotechnology · Jan 1, 2026Peer-reviewedMicrobiology

Barcoded bulk QTL mapping reveals highly polygenic and epistatic architecture of complex traits in yeast

Alex N. Nguyen Ba, Katherine R. Lawrence, Artur Rego‐Costa, Shreyas Gopalakrishnan, Daniel Temko, Franziska Michor A, Michael M. Desai

The paper introduces BB-QTL mapping to study complex traits in yeast, revealing polygenic, pleiotropic, and epistatic genetic architectures with increased sample size.

eLife · Feb 11, 2022Peer-reviewedGenetics