Tiago J. S. Lopes

The paper reports a new bat betacoronavirus from Brazil with a functional furin cleavage site in its spike protein, highlighting its phylogenetic distinctiveness and potential zoonotic risk.

This paper develops engineered FVIII variants for hemophilia A gene therapy, showing improved secretion, coagulation activity, and efficacy at lower vector doses in mice and macaques.

The paper identifies host factors critical for influenza virus replication by analyzing network positions of virus-host interactions and validates them through an siRNA screen.