Cell BiologyCell CalciumPeer-reviewed
SERCA2b loss of function drives pigmentation by inducing adaptive ER stress and enhancing mitochondrial calcium uptake: significance in pathological hyperpigmentation associated with Darier’s Disease
Akshay Sharma, Suman Saurav, Preity Sharma…·Rajender K. Motiani
This study identifies SERCA2b as a negative regulator of pigmentation through ER stress and mitochondrial calcium uptake, linking its loss to hyperpigmentation in Darier’s Disease.
DOI 10.1016/j.ceca.2026.103199