Rajender K. Motiani

The IFN-γ-inducible GTPase IIGP1 regulates mitochondrial remodeling and immunometabolic reprogramming during inflammatory macrophage polarization

TRPM2 couples cell-autonomous type-I interferon signaling to pigmentation homeostasis

This study identifies TRPM2 as a suppressor of pigmentation through type-I interferon signaling in melanocytes, revealing a novel signaling axis linking immune surveillance to pigmentation homeostasis.

SERCA2b loss of function drives pigmentation by inducing adaptive ER stress and enhancing mitochondrial calcium uptake: significance in pathological hyperpigmentation associated with Darier’s Disease

This study identifies SERCA2b as a negative regulator of pigmentation through ER stress and mitochondrial calcium uptake, linking its loss to hyperpigmentation in Darier’s Disease.

Alcohol-Evoked Calcium Signaling Drives Distinct Responses in Zebrafish Hepatocytes and Pancreatic Acinar Cells

This study shows alcohol exposure causes shared calcium signaling changes in zebrafish hepatocytes and pancreatic acinar cells, with tissue-specific molecular mechanisms involved.

NFAT2 drives both Orai3 transcription and protein degradation by harnessing the differences in epigenetic landscape of MARCH8 E3 ligase

This paper shows NFAT2 regulates Orai3 expression differently in non-metastatic and metastatic cancer cells through transcriptional activation and MARCH8-mediated degradation, linked to MARCH8 promoter methylation.

Orai3 orchestrates gemcitabine resistance in pancreatic cancer via NFATc1-SLIT3 axis

This paper identifies Orai3 as a driver of gemcitabine resistance in pancreatic cancer through the Orai3-NFATc1-SLIT3 signaling pathway, showing its role in cell proliferation, apoptosis, and metastasis.

SNHG10 promote tumorigenesis via miR-150/VEGFA/EGFR/AKT/ERK/mTOR axis and gemcitabine resistance in PDAC

IP3R2 mediated inter-organelle Ca2+ signaling orchestrates melanophagy

This paper identifies IP3R2 as a negative regulator of melanophagy, showing it controls melanosome degradation through Ca2+ signaling and lysosomal pathways.

LncRNA TAAL is a Modulator of Tie1-Mediated Vascular Function in Diabetic Retinopathy

This study identifies TAAL, a lncRNA that modulates Tie1 signaling and vascular function in diabetic retinopathy, showing its role in endothelial cell behavior and potential therapeutic relevance.

Remodeling Ca2+ dynamics by targeting a promising E-box containing G-quadruplex at ORAI1 promoter in triple-negative breast cancer.

The paper identifies a G-quadruplex in the ORAI1 promoter that regulates transcription and Ca2+ dynamics in triple-negative breast cancer.

Histone code dictates fate biasing of neural crest cells to melanocyte lineage

This study identifies H2a.z.2 as a histone variant that biases neural crest cells toward the melanocyte lineage by enhancing Mitf promoter activation.