Author

Akshay Sharma

Regional Centre for BiotechnologyORCID 0009-0004-9251-6377Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Rajender K. MotianiiD· 3 shared Gyan RanjaniD· 2 shared Suman Saurav· 2 shared Anindya DuttaiD· 1 shared Anushka AgrawaliD· 1 shared Deepika PandhiiD· 1 shared Divya Bhalla· 1 shared Jagannath JanaiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersCell Biology

Rajender K. MotianiORCID

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3 papers

Recent·Most cited

Cell BiologyCell CalciumPeer-reviewedSep 24, 2026

SERCA2b loss of function drives pigmentation by inducing adaptive ER stress and enhancing mitochondrial calcium uptake: significance in pathological hyperpigmentation associated with Darier’s Disease

Akshay Sharma, Suman Saurav, Preity Sharma…·Rajender K. Motiani

This study identifies SERCA2b as a negative regulator of pigmentation through ER stress and mitochondrial calcium uptake, linking its loss to hyperpigmentation in Darier’s Disease.

DOI 10.1016/j.ceca.2026.103199

humanexperimental assay

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Cell BiologyThe EMBO JournalPeer-reviewedSep 29, 2025

NFAT2 drives both Orai3 transcription and protein degradation by harnessing the differences in epigenetic landscape of MARCH8 E3 ligase

Sharon Raju, Akshay Sharma, Sakshi Dahiya…·Rajender K. Motiani

This paper shows NFAT2 regulates Orai3 expression differently in non-metastatic and metastatic cancer cells through transcriptional activation and MARCH8-mediated degradation, linked to MARCH8 promoter methylation.

8 citations

humanproteomics

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BiochemistryCell CalciumPeer-reviewedAug 12, 2024

Remodeling Ca2+ dynamics by targeting a promising E-box containing G-quadruplex at ORAI1 promoter in triple-negative breast cancer.

Oishika Chatterjee, Jagannath Jana, Suman Panda…·Subhrangsu Chatterjee

The paper identifies a G-quadruplex in the ORAI1 promoter that regulates transcription and Ca2+ dynamics in triple-negative breast cancer.

2 citations

humanChIP-seq

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