Cell BiologybioRxivPreprint
TTC7A organizes glandular lumen formation in the intestine through a Class II phosphatidylinositol 3-kinase
Katlynn Bugda Gwilt, Dhanushan Wijayaratna, Geordie Emberling…·Jay R. Thiagarajah
This study identifies TTC7A's role in intestinal lumen formation by chaperoning PIK3C2A to generate PI(3,4)P2, with loss-of-function variants causing multiple lumens and rescue possible via exogenous PI(3,4)P2.
DOI 10.1101/2025.03.22.644724