Author

Jeffrey La

Boston Children's HospitalORCID 0000-0002-9407-9121Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Bioengineering· 1 Cell Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1 Assay:scRNA-seq· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Jay R. ThiagarajahiD· 3 shared Krishnan RaghunathaniD· 3 shared Lily GilletteiD· 2 shared Michael D. Anderson· 2 shared Scott B. SnapperiD· 2 shared Abigail Plone· 1 shared Abigail PloneiD· 1 shared Adam R. Greene· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersDevelopmental Biology

Jay R. ThiagarajahORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Development of the Early Childhood Duodenum across Ancestry, Geography and Environment

Joshua de Sousa Casal, Krishnan Raghunathan, Chelsea Asare, Abigail Plone, Nazanin Moradinasab, Junaid Iqbal, Lianna Wood, Elsy M. Ngwa, Xia Chen, S. Fisher Rhoads, Clara Baek, Dur-e Shahwar, Neha S. Dhaliwal, Madison Wong, Max Garrity-Janger, , Jay R. Thiagarajah

The paper creates a cellular and spatial map of the duodenum in children, revealing environmental and developmental influences on intestinal cell states.

bioRxiv · Dec 17, 2025 · PreprintDevelopmental Biology

SPECTRE-Plex: an automated, fast, high-resolution-enabled approach for multiplexed cyclic imaging and tissue spatial analysis

Michael D. Anderson, Abigail Plone, Jeffrey La, Madison Wong, Krishnan Raghunathan, Jocelyn Anne Silvester, Jay R. Thiagarajah

SPECTRE-Plex improves speed, automation, and resolution for cyclic multiplex immunofluorescence imaging to better map tissue spatial organization.

Communications Biology · Apr 19, 2025Peer-reviewedBioengineering

TTC7A organizes glandular lumen formation in the intestine through a Class II phosphatidylinositol 3-kinase

Katlynn Bugda Gwilt, Dhanushan Wijayaratna, Geordie Emberling, Lily Gillette, Jeffrey La, Hengqi Betty Zheng, Danielle Wendel, Lina B. Karam, Aleixo M. Muise, Scott B. Snapper, Wayne I. Lencer, Krishnan Raghunathan, Jay R. Thiagarajah

This study identifies TTC7A's role in intestinal lumen formation by chaperoning PIK3C2A to generate PI(3,4)P2, with loss-of-function variants causing multiple lumens and rescue possible via exogenous PI(3,4)P2.

bioRxiv · Mar 22, 2025 · PreprintCell Biology