Author

Mrudula Sane

National Centre for Biological SciencesORCID 0000-0001-9616-8454Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Evolutionary Biology· 2

Signature Assays, Organisms & Methods

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Organism:E. coli· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Deepa AgasheiD· 2 shared Aakanksha MadhwaliD· 1 shared Ruchith BK· 1 shared Shazia ParveeniD· 1 shared Shazia ParveeniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

5 top collaborators · 7 mutual co-author links

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2 shared papersEvolutionary Biology

Deepa AgasheORCID

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2 papers

Recent·Most cited

Evolutionary BiologybioRxivPreprintSep 22, 2025

Mutation bias is a key predictor of adaptation rate

Shazia Parveen, Aakanksha Madhwal, Ruchith BK…·Deepa Agashe

This study shows mutation bias reversal increases E. coli adaptation rate by 5% and reduces variation across populations.

DOI 10.1101/2025.09.22.677663

E. coliexperimental assay

𝕏 PostBluesky

Evolutionary BiologyPLoS BiologyPeer-reviewedJul 14, 2025

Mutation bias alters the distribution of fitness effects of mutations

Mrudula Sane, Shazia Parveen, Deepa Agashe

The paper tests how changing mutation bias affects the distribution of fitness effects in E. coli, finding that reversing the mutation bias increases the proportion of beneficial mutations.

16 citationstop 3%

E. coliexperimental assay

𝕏 PostBluesky