Jessica Kaster

This study uses single-cell lineage tracing to map clonal and transcriptional dynamics in melanoma metastasis, identifying distinct transcriptional programs and spatial organization patterns.

This study identifies drug-tolerant persister states in melanoma using MeRLin, showing their role in resistance and tumor recurrence.

SpaceBar enables clone tracing and spatial transcriptomics profiling by using synthetic barcodes to label cells and analyze gene expression in situ.

The paper develops a Nextflow pipeline for processing Visium spatial transcriptomics and H&E images from PDX samples, enabling multi-modal analysis and integration of spatial gene expression and morphometric features.

This study uses spatial transcriptomics and deep learning to analyze melanoma treatment resistance, identifying persister states and resistance mechanisms with spatiotemporal resolution.