Haiyin Li

This study uses single-cell lineage tracing to map clonal and transcriptional dynamics in melanoma metastasis, identifying distinct transcriptional programs and spatial organization patterns.

This study identifies drug-tolerant persister states in melanoma using MeRLin, showing their role in resistance and tumor recurrence.

The paper identifies the MYC-ATF4-ASS1 axis in melanoma that controls arginine synthesis and modulates immune responses, showing therapeutic potential with arginine depletors and BRAF/MEK inhibitors.

SpaceBar enables clone tracing and spatial transcriptomics profiling by using synthetic barcodes to label cells and analyze gene expression in situ.

This study uses spatial transcriptomics and deep learning to analyze melanoma treatment resistance, identifying persister states and resistance mechanisms with spatiotemporal resolution.

The paper develops a Nextflow pipeline for processing Visium spatial transcriptomics and H&E images from PDX samples, enabling multi-modal analysis and integration of spatial gene expression and morphometric features.