Dual inhibition of lactate transporters MCT1 and MCT4 in pancreatic neuroendocrine tumors targets metabolic heterogeneity and functional redundancy
Konstantin Bräutigam, Janine Straub, Abdulloh K Bihi, Renaud Maire, Simona Avanthay, Kristina Fillipova, Valentina Andreasi, Anna Battistella, Philipp Kirchner, Matthias S. Dettmer, Joerg Schrader, Marco Schiavo Lena, Stefano Partelli, Massimo Falconi, Ilaria Marinoni, , Aurel A. Perren
The paper investigates MCT1 and MCT4 expression in PanNETs, showing their role in metabolic heterogeneity and functional redundancy, and demonstrates that dual inhibition targets tumor aggressiveness.
bioRxiv · Jan 31, 2025 · PreprintCancer Biology