Lorenzo Pasquali

This study compares immunotherapy responses in subcutaneous and orthotopic dMMR LUAD models, finding that orthotopic models show better anti-PD1 response with increased immune infiltration and CD4+ memory T cells.

This study identifies noncoding regulatory regions and their mutations in insulinomas, linking them to altered β-cell function and tumor development.

This study identifies 15 novel ductal cell populations in the mouse pancreas using scRNA-seq and investigates their roles in regeneration and exocrine pathogenesis.

This study shows that pro-inflammatory cytokines reveal plasticity in β-cell regulatory landscapes and identify T1D-associated variants disrupting cytokine-responsive enhancers.

The paper links diabetes-associated enhancers with their target genes using 3D chromatin architecture in human pancreatic islets, revealing genetic variants that impact insulin secretion heritability.

This study identifies β cell-specific lncRNAs that regulate transcriptional networks and show dysregulation in type 2 diabetes.