Marc D. Schwabenlander

The paper investigates whether DNA extraction methods co-purify prions, finding that commercial kits do not eliminate prion seeding activity, posing biosafety risks.

This study demonstrates that CWD prions can contaminate processing surfaces and be transferred to CWD-negative venison, but can be inactivated using bleach and potassium peroxymonosulfate.

This study establishes a standardized method using maxpoint ratios (MPR) to improve consistency in RT-QuIC analysis for detecting chronic wasting disease.

The paper develops a field-deployable diagnostic assay, MN-QuIC, for visual detection of misfolded prions in CWD-infected deer, showing 100% consistency with established tests.

This study uses RT-QuIC to detect CWD prion seeding activity in skeletal muscles of infected white-tailed deer, finding prions in consumption-relevant tissues and highlighting their broader distribution.