Peter A. Larsen

This study develops an optimized Nano-QuIC platform to detect alpha-synuclein oligomers in human plasma with high sensitivity for early Parkinson's disease diagnosis.

The paper investigates whether DNA extraction methods co-purify prions, finding that commercial kits do not eliminate prion seeding activity, posing biosafety risks.

This study evaluates nanopore adaptive sampling for detecting Borrelia burgdorferi in ticks, finding it highly specific but with moderate sensitivity and high false-negative rates.

AI-QuIC automates RT-QuIC assay analysis for misfolded protein detection, achieving high sensitivity and specificity using deep learning on a large prion dataset.

This study demonstrates that CWD prions can contaminate processing surfaces and be transferred to CWD-negative venison, but can be inactivated using bleach and potassium peroxymonosulfate.

QuICSeedR automates F-SAA data analysis, improving consistency and reproducibility across labs.

This paper develops a method using nanopore adaptive sampling to rapidly identify mammalian species from scat samples, achieving accurate identifications for most samples and detecting a misidentification in one case.

The paper investigates how high neuropeptide-producing neurons contribute to Alzheimer's disease vulnerability by analyzing transcriptomic changes and their distribution in affected brain regions.

This paper introduces Nano-QuIC, a method that improves the detection of misfolded α-synuclein in blood samples from Parkinson's patients compared to traditional RT-QuIC.

This study uses single-cell and bulk transcriptomic data to show widespread disruption of neuropeptide networks in Alzheimer's disease entorhinal cortex, with decreased NP expression and increased GPCR expression.

This paper uses the Oxford Nanopore Adaptive Sampling pipeline to sequence mitogenomes of hematophagous insects and identify their bloodmeal hosts, aiding in disease transmission studies.

This study establishes a standardized method using maxpoint ratios (MPR) to improve consistency in RT-QuIC analysis for detecting chronic wasting disease.

The paper develops a field-deployable diagnostic assay, MN-QuIC, for visual detection of misfolded prions in CWD-infected deer, showing 100% consistency with established tests.

The paper reports a new mitogenome assembly for the golden lion tamarin using nanopore adaptive sequencing and detects DNA hydroxymethylation in mitochondria.

This study uses RT-QuIC to detect CWD prion seeding activity in skeletal muscles of infected white-tailed deer, finding prions in consumption-relevant tissues and highlighting their broader distribution.

The paper compares UV repair efficiency and patterns between humans and mouse lemurs, finding similar repair mechanisms but differences in efficiency.

The paper demonstrates the use of a mobile genetics lab in Madagascar to conduct in situ DNA sequencing and provide training for local scientists.

The paper compares V1R gene diversity in nocturnal and diurnal lemurs, finding a correlation between nocturnality and expanded V1R repertoires.

The paper discusses the dual role of Alu elements in shaping human brain evolution and contributing to neurological diseases through epigenetic dysregulation of mitochondrial genes.