A workflow integrating organ-on-chip culture and correlative 3D light and electron microscopy for microtissue analysis
Judith M. Schaart, Dorothee Wasserberg, Marcos Antônio Eufrásio Cruz, Mariska Kea‐te Lindert, Robin H. M. van der Meijden, Rona Roverts, Nataliya Debera, Minh Phu Lu, Jeroen Rouwkema, Wouter H. Nijhuis, Andries D. van der Meer, Pascal Jonkheijm, Nico A. J. M. Sommerdijk, Anat Akiva
This paper presents a workflow combining organ-on-chip culture with 3D light and electron microscopy for microtissue analysis, demonstrating the feasibility of extended live imaging and focused ion beam/SEM for ultrastructural study.
Scientific Reports · Dec 11, 2025Peer-reviewedBioengineering