Nathalie Jouvet

This study shows that the PGC-1α Gly482Ser SNP reprograms oxidative metabolism to favor energy storage, especially in females, through reduced respiratory capacity and altered metabolic responses.

This study shows that reduced NCK1 in beta cells of type 2 diabetes patients impairs the unfolded protein response and insulin secretion, with sex-specific adaptive responses observed in mice.

The paper investigates how different PGC-1α isoforms regulate hepatic metabolism and apoptosis in response to inflammation, identifying distinct roles for PGC-11 and PGC-14.