β-cell NCK1 is reduced in type 2 diabetes, impairing the unfolded protein response and insulin secretion while revealing sex-specific adaptation
Laure Monteillet, Nathalie Jouvet, Rebbeca Huet, Justine Touzot, Lili Grieco-St-Pierre, Maria Galipeau, Clémence Schmitt, M. Schoumacher, Émilie Courty, Cindy Baldwin, Steven Paraskevas, Jennifer L. Estall
This study shows that reduced NCK1 in beta cells of type 2 diabetes patients impairs the unfolded protein response and insulin secretion, with sex-specific adaptive responses observed in mice.
bioRxiv · Jul 22, 2026 · PreprintPhysiology