Yabing Chen

This paper introduces mmFEA, a kinetic-aware framework for estimating metabolic flux changes from transcriptomics and metabolomics data, showing improved accuracy over baseline methods.

This study shows maternal obesity causes sex-dependent epigenetic and transcriptomic changes in offspring hearts, leading to sex-specific cardiac remodeling and disease risk.

ACCREDIT improves cross-modal image registration by detecting failures and automatically recovering alignments, outperforming existing methods in accuracy and robustness.

This study shows medin induces pro-inflammatory and prothrombotic changes in endothelial cells and is strongly associated with coronary plaque burden and inflammation.

This study identifies FNDC1 as a key regulator of vascular calcification through the FNDC1-NAMPT-NAD axis, showing its role in both microvascular and macrovascular diseases and its potential as a therapeutic target.

This study shows PRMT1 promotes leukemogenesis by enhancing glycolysis and reducing fatty acid oxidation in AMKL cells.

The paper constructs a transcriptomic atlas of immune cells across human lifespan and develops a biological age prediction model using scRNA-seq and bulk RNA-seq data.

This study shows that Bmal1 in vascular smooth muscle cells promotes vascular calcification under diabetic conditions, independent of the canonical circadian pathway.

This study shows Epsins regulate smooth muscle cell reprogramming by modulating OCT4 and KLF4, with implications for coronary artery disease.