Richard J. Weinberg

The paper uses proteometric imaging to classify synapses by glutamate receptor subunits, finding subclasses linked to synaptic plasticity and dendritic coupling.

The paper develops a screening strategy and database of antibodies validated for array tomography-based imaging of brain synapses, improving antibody selection for this technique.

The paper confirms the presence of myelinated inhibitory axons in all layers of human neocortex, similar to findings in mice, and identifies their distinctive features and potential implications for neurological disorders.

The paper introduces a framework for characterizing and screening antibodies against synaptic molecules for array tomography, providing objective metrics to evaluate antibody performance.