Kristina D. Micheva

The paper uses proteometric imaging to classify synapses by glutamate receptor subunits, finding subclasses linked to synaptic plasticity and dendritic coupling.

The paper develops a screening strategy and database of antibodies validated for array tomography-based imaging of brain synapses, improving antibody selection for this technique.

This study tracks the development of parvalbumin basket cell axons in mice, revealing rapid myelination, synapse pruning, and axonal reorganization that refine inhibitory connectivity.

The paper measures conduction velocity in parvalbumin interneurons and finds that axonal myelination significantly increases action potential propagation speed.

This study examines synapse-type and astrocytic changes in a FXS mouse model, revealing layer-specific synaptic density alterations and reduced astrocytic association in excitatory synapses.

The paper confirms the presence of myelinated inhibitory axons in all layers of human neocortex, similar to findings in mice, and identifies their distinctive features and potential implications for neurological disorders.

The paper introduces a framework for characterizing and screening antibodies against synaptic molecules for array tomography, providing objective metrics to evaluate antibody performance.