Ashley P. Ng

DesignMaster improves PROTAC design by incorporating linker length and physicochemical constraints through a diffusion framework, achieving better validity and recovery than existing methods.

MolX is a geometric foundation model that jointly learns representations of protein pockets and ligands from 3D structural data, achieving state-of-the-art performance in predicting molecular interactions.

This study identifies WEHI-092, a USP9X inhibitor, and shows it arrests cancer cells in metaphase, suggesting USP9X inhibitors could be selective mitotic poisons.

This study uses cellular barcoding and agent-based modeling to reveal clonal fate patterns in hematopoiesis, showing that stem and progenitor cells are often less multipotent than previously thought.

The paper demonstrates that intron reads from RNA-seq are informative and introduces methods to analyze them for transcriptional changes and intron retention.