Author
InsermORCID 0000-0001-9716-755XUnclaimed ORCID profile · follow to get notified of new preprints
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5 papers
Recent·Most cited
Hoa Nguyen, Audrey Desgrange, Amaia Ochandorena-Saa…·Christophe Zimmer
This paper develops deep learning models to automatically detect congenital heart defects in mouse CT scans, achieving high accuracy across different cohorts.
Tobias Holm Bønnelykke, Marie-Amandine Chabry, Émeline Perthame…·Sigolène M. Meilhac
The paper identifies Notch3 as a genetic modifier of Nodal signaling that influences heart looping asymmetry in mice.
Ségolène Bernheim, Adrien Borgel, Jean‐François Le Garrec…·Sigolène M. Meilhac
The paper identifies Greb1l as a genetic determinant of criss-cross heart in mice by showing its role in maintaining precursor cells during heart tube elongation.
Audrey Desgrange, Jean‐François Le Garrec, Ségolène Bernheim…·Sigolène M. Meilhac
This study shows Nodal transiently coordinates left-right asymmetries in mouse heart development through a heart-specific random generator, amplifying asymmetry to generate a robust helical shape.
Audrey Desgrange, Johanna Lokmer, Carmen Marchiol…·Sigolène M. Meilhac
The paper develops a standardized multimodality imaging pipeline for 3D phenotyping of laterality defects and heart malformations in mice across multiple scales and stages.