Sigolène M. Meilhac

The paper shows that Wnt and Nodal asymmetries contribute to left-right asymmetry in mice despite the absence of node flow, suggesting a novel mechanism for symmetry breaking.

This paper develops deep learning models to automatically detect congenital heart defects in mouse CT scans, achieving high accuracy across different cohorts.

This study identifies novel epithelial roles of VANGL2 in shaping the mouse heart tube through cell rearrangements and midline symmetry control, independent of planar polarity.

The paper identifies Notch3 as a genetic modifier of Nodal signaling that influences heart looping asymmetry in mice.

The paper identifies Greb1l as a genetic determinant of criss-cross heart in mice by showing its role in maintaining precursor cells during heart tube elongation.

This study investigates the embryonic origin of coronary artery fistulas (CAFs) using animal models and shows that myocardial discontinuities in the ventricular wall cause CAF formation through abnormal epicardial-endocardial interactions.

This study shows that IFT complex B proteins modulate YAP1 activity during cardiogenesis in zebrafish and mouse, linking cilia-related proteins to Hippo pathway regulation.

This study shows Nodal transiently coordinates left-right asymmetries in mouse heart development through a heart-specific random generator, amplifying asymmetry to generate a robust helical shape.

The paper develops a standardized multimodality imaging pipeline for 3D phenotyping of laterality defects and heart malformations in mice across multiple scales and stages.