ImmunologybioRxivPreprint
Controlling TCR and CAR activation by targeting LCK recruitment with a first-in-class small-molecule inhibitor
Nadine M. Woessner, Patricio Chinestrad, Tamina Rückert…·Susana Minguet
This study identifies a small-molecule inhibitor that selectively disrupts LCK recruitment to CD3ε, reducing TCR activation while preserving other immune responses.
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