Susana Minguet

This study maps the postnatal differentiation trajectories of dendritic epidermal T cells and Langerhans cells in mice, showing they develop independently of each other and microbial colonization.

This study identifies a small-molecule inhibitor that selectively disrupts LCK recruitment to CD3ε, reducing TCR activation while preserving other immune responses.

This study shows that LCK deficiency in CD8 T cells reduces proliferation but increases effector T-cell formation in mice, revealing its dual role in T-cell responses.

The paper develops a γδT-omics pipeline to analyze compartmentalization of Vδ1⁺ T cell migration, tumor-reactivity, and clonality in human colorectal cancer, revealing distinct functional and transcriptional features across tumor compartments.