Z. Niu

Amphetamine in Adolescence Induces a Sex-Specific Mesolimbic Dopamine Phenotype in the Adult Prefrontal Cortex

This study shows that adolescent amphetamine exposure causes sex-specific changes in mesolimbic dopamine axons and PFC dopamine transporter expression in adulthood, with males showing increased vulnerability to drug effects.

Adaptive immunity: from CRISPR to CRIHSP?

The paper identifies CRIHSP structures in human adaptive immunity genes, showing their association with genomic instability and recombination.

Multimodal engineering of extracellular vesicles for efficient intracellular protein delivery

This paper develops VEDIC and VFIC systems for efficient intracellular protein delivery using engineered extracellular vesicles, achieving high recombination and genome editing efficiency in vitro and in vivo.

Novel endogenous engineering platform for robust loading and delivery of functional mRNA by extracellular vesicles

This paper develops an mRNA delivery system using extracellular vesicles engineered with RNA-binding domains and fusogenic moieties, showing improved efficacy in a melanoma model.

Humanized CD36 mouse model supports the preclinical evaluation of therapeutic candidates targeting CD36

This study creates a CD36 humanized mouse model to evaluate CD36-targeting therapies, showing that anti-CD36 antibodies inhibit tumor growth.

Fossil-explorer.com: An efficient interactive approach to exploring fossil data

Fossil-explorer.com is an interactive tool for exploring fossil data that addresses visual clutter and limited interaction, efficiently handling millions of data points.

Lentiviral vector optimization enhances the expression and cytotoxicity of chimeric antigen receptors

This study compares single-promoter and dual-promoter lentiviral vectors for CAR expression and cytotoxicity in engineered NK cells, finding that the single-promoter pCDHsp enhances expression and cytotoxicity.

AIM-CICs: automatic identification method for Cell-in-cell structures based on convolutional neural network

This study develops AIM-CICs, an AI-based method using CNN to automatically identify and classify cell-in-cell structures, improving efficiency and accuracy over manual methods.

Thinopyrum intermedium TiAP1 interacts with a chitin deacetylase from Blumeria graminis f. sp. tritici and increases the resistance to Bgt in wheat

This study identifies TiAP1 from Thinopyrum intermedium as a resistance gene against Blumeria graminis f. sp. tritici, showing it interacts with BgtCDA1 and enhances wheat resistance through immune activation.

Role and Dynamics of Vacuolar pH during Cell-in-Cell mediated Death

This study uses pH-sensitive fluorescent protein to track vacuolar pH changes during cell-in-cell mediated death, revealing distinct pH dynamics in entotic and apoptotic death and their implications for cancer treatment.

Systemic analysis of tissue cells potentially vulnerable to SARS-CoV-2 infection by the protein-proofed single-cell RNA profiling of ACE2, TMPRSS2 and Furin proteases

The paper uses protein-proofed single-cell RNA profiling to identify tissue cells vulnerable to SARS-CoV-2 infection across 36 tissues, revealing lung and cardiac cells as top targets.

Counteracting Genome Instability by p53-dependent Mintosis

The paper identifies a p53-dependent process called mintosis that eliminates aneuploid mitotic progenies through entosis to counteract genome instability.