Author

Jeffrey A. Frost

The University of Texas Health Science Center at HoustonORCID 0000-0001-9722-1536Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:experimental assay· 1 Organism:mouse· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1 Assay:whole-exome sequencing· 1 Organism:zebrafish· 1

Frequent Co-Authors

Abraham C. SianoyaiD· 1 shared Alemayehu Abebe GorfeiD· 1 shared Ashabari Sprenger· 1 shared C. Ravindranath Kamath· 1 shared Cynthia V. PagbaiD· 1 shared Hope NorthrupiD· 1 shared Jacob L. JakubeciD· 1 shared Kit Sing AuiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Abraham C. SianoyaORCID

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2 papers

Recent·Most cited

Cancer BiologyMolecular Cancer TherapeuticsPeer-reviewedMar 14, 2026

MRTX1133 is a potent non-covalent KRAS (G12C) inhibitor with tissue-specific activity

Abraham C. Sianoya, Yan Zuo, Cynthia V. Pagba…·Alemayehu Abebe Gorfe

This paper shows that MRTX1133, a non-covalent KRAS (G12D) inhibitor, also inhibits KRAS (G12C) with high affinity and suppresses MAPK signaling in pancreatic cancer cells but not lung cancer cells.

5 citationstop 1%

humanexperimental assay

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Genetic & Genomic MedicinemedRxivPreprintJun 12, 2025

Focal Adhesion Kinase Variants May Contribute to Risk of Human Myelomeningocele

Lydia Youmans, C. Ravindranath Kamath, Sara Mansoorshahi…·Kit Sing Au

The paper identifies PTK2 variants associated with myelomeningocele risk through exome sequencing and functional assays in mice and Xenopus.

DOI 10.1101/2025.06.12.25329493

humanmouse

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