Alemayehu Abebe Gorfe

This study identifies DIRAS3 as a tumor suppressor that inhibits diverse oncogenic KRAS variants through a specific inhibitory interface, with a mimetic showing broad suppression of KRAS-driven signaling.

This paper shows that MRTX1133, a non-covalent KRAS (G12D) inhibitor, also inhibits KRAS (G12C) with high affinity and suppresses MAPK signaling in pancreatic cancer cells but not lung cancer cells.

This study uses simulations and assays to show Rheb switches between membrane orientations, affecting mTORC1 activity.

This study models GPR174 bound to an antagonist and compares its dynamics to LysoPS, revealing distinct ligand-specific mechanisms and potential for immunotherapeutic antagonists.

This study uses molecular dynamics simulations to analyze how intrinsically disordered regions of small GTPases interact with membranes, showing that lipid sequence complementarity and electrostatic interactions influence conformational dynamics and lipid sorting.