Author

Cynthia V. Pagba

The University of Texas Health Science Center at HoustonORCID 0000-0002-3642-4361Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alemayehu Abebe GorfeiD· 2 shared Jacob L. JakubeciD· 2 shared Abraham C. SianoyaiD· 1 shared Chase M. Hutchins· 1 shared Geetika Verma· 1 shared Guangwei DuiD· 1 shared Jeffrey A. FrostiD· 1 shared Paul Mark B. MedinaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

Alemayehu Abebe GorfeORCID

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2 papers

Recent·Most cited

Cancer BiologyMolecular Cancer TherapeuticsPeer-reviewedMar 14, 2026

MRTX1133 is a potent non-covalent KRAS (G12C) inhibitor with tissue-specific activity

Abraham C. Sianoya, Yan Zuo, Cynthia V. Pagba…·Alemayehu Abebe Gorfe

This paper shows that MRTX1133, a non-covalent KRAS (G12D) inhibitor, also inhibits KRAS (G12C) with high affinity and suppresses MAPK signaling in pancreatic cancer cells but not lung cancer cells.

5 citationstop 1%

humanexperimental assay

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BiophysicsbioRxivPreprintMar 2, 2026

Rheb membrane orientation dynamics and functional consequences elucidated by molecular simulations, single-molecule-FRET and signaling assays

Chase M. Hutchins, Cynthia V. Pagba, Geetika Verma…·Alemayehu Abebe Gorfe

This study uses simulations and assays to show Rheb switches between membrane orientations, affecting mTORC1 activity.

DOI 10.64898/2026.02.27.708535

humanmechanistic / dynamical model

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