Author

Abraham C. Sianoya

University of the Philippines ManilaORCID 0000-0002-5070-7843Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Alemayehu Abebe GorfeiD· 1 shared Cynthia V. PagbaiD· 1 shared Jacob L. JakubeciD· 1 shared Jeffrey A. FrostiD· 1 shared Paul Mark B. MedinaiD· 1 shared Stephanie A. PlanqueiD· 1 shared Yan ZuoiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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7 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Alemayehu Abebe GorfeORCID

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1 paper

Recent·Most cited

Cancer BiologyMolecular Cancer TherapeuticsPeer-reviewedMar 14, 2026

MRTX1133 is a potent non-covalent KRAS (G12C) inhibitor with tissue-specific activity

Abraham C. Sianoya, Yan Zuo, Cynthia V. Pagba…·Alemayehu Abebe Gorfe

This paper shows that MRTX1133, a non-covalent KRAS (G12D) inhibitor, also inhibits KRAS (G12C) with high affinity and suppresses MAPK signaling in pancreatic cancer cells but not lung cancer cells.

5 citationstop 1%

humanexperimental assay

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