Wouter A. S. Doff

This study shows that tubulin overexpression causes proteostasis defects and replication stress by disrupting mitochondrial translation and cell cycle regulation.

This study uses proteomics to show that USP7's deubiquitylation effects are substrate-specific, revealing its role in neurodevelopment and tumor suppression.

The paper identifies USP7's role in neuronal differentiation by regulating BCOR-ncPRC1.1, revealing a shared epigenetic network in neurodevelopmental disorders.

This study characterizes cytotrophoblast dynamics during pregnancy using single-cell RNA sequencing, identifying distinct subsets and their functional roles.

This study identifies bi-allelic XPNPEP3 variants causing mitochondrial disease with pediatric cardiomyopathy, revealing impaired mitochondrial protein processing as the underlying mechanism.