Author

Jan A. van der Knaap

Erasmus MCORCID 0000-0002-9175-6086Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

C. Peter VerrijzeriD· 3 shared Dick H. W. DekkersiD· 3 shared Jeroen DemmersiD· 3 shared Ayestha SijmiD· 2 shared Ben C. Tilly· 2 shared Gillian E. ChalkleyiD· 2 shared Joyce Wolf van der MeeriD· 2 shared Karel Bezstarosti· 2 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMolecular Biology

C. Peter VerrijzerORCID

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3 papers

Recent·Most cited

Proteome-wide ubiquitinome profiling reveals substrate-specific dynamics within the USP7 network

Joyce Wolf van der Meer, Jan A. van der Knaap, Ayestha Sijm, Karel Bezstarosti, Dick H. W. Dekkers, Wouter A. S. Doff, Jeroen Demmers, C. Peter Verrijzer

This study uses proteomics to show that USP7's deubiquitylation effects are substrate-specific, revealing its role in neurodevelopment and tumor suppression.

Molecular & Cellular Proteomics · Jun 16, 2026Peer-reviewedBiochemistry

Hao-Fountain syndrome protein USP7 controls neuronal differentiation via BCOR-ncPRC1.1

Joyce Wolf van der Meer, Axelle Larue, Jan A. van der Knaap, Gillian E. Chalkley, Ayestha Sijm, Leila Beikmohammadi, Elena N. Kozhevnikova, Aniek van der Vaart, Ben C. Tilly, Karel Bezstarosti, Dick H. W. Dekkers, Wouter A. S. Doff, P. Jantine van de Wetering-Tieleman, Kristina Lanko, Tahsin Stefan Barakat, , C. Peter Verrijzer

The paper identifies USP7's role in neuronal differentiation by regulating BCOR-ncPRC1.1, revealing a shared epigenetic network in neurodevelopmental disorders.

Genes & Development · Mar 1, 2025Peer-reviewedMolecular Biology

In vivo Analysis Reveals that ATP-hydrolysis Couples Remodeling to SWI/SNF Release from Chromatin

Ben C. Tilly, Gillian E. Chalkley, Jan A. van der Knaap, Yuri M. Moshkin, Tsung Wai Kan, Dick H. W. Dekkers, Jeroen Demmers, C. Peter Verrijzer

The paper shows ATP hydrolysis enables chromatin remodeler release, allowing continuous genome probing by limiting BRM chromatin binding.

eLife · Jul 27, 2021Peer-reviewedMolecular Biology