Ricardo da Silva Antunes

COMBO-RATE identifies promiscuous HLA restrictions by analyzing immune response data, outperforming existing tools and revealing broader HLA allele coverage for T cell epitopes.

This study examines T cell and antibody responses in vaccinated individuals over three years, finding stable T cell responses and increased regulatory T cells after multiple boosters.

This study compares immune responses to whole-cell and acellular pertussis vaccines, finding that Th1 polarization is maintained through an early interferon response in whole-cell vaccine recipients.

This paper develops a machine learning model that integrates peptide and antigen features to predict immunogenic CD4+ T cell epitopes in bacteria, achieving high accuracy across multiple bacterial species.

The paper evaluates computational models predicting immune responses to Pertussis Booster vaccinations using a new community resource, finding that existing models perform poorly and new models show variable performance based on features and strategies.

The paper compares immune responses to a Tdap booster in adults primed with acellular (aP) or whole-cell (wP) pertussis vaccines, identifying divergent gene expression and antibody subtype patterns in aP-primed individuals.