Ane Martinez‐Larrinaga

The paper constructs a pan-cancer single-cell RNA sequencing atlas of pericytes, revealing a common transcriptional program in tumour-associated pericytes and their specialised subtypes across multiple cancers.

This study shows that PIK3CAH1047R mutation causes clonal expansion in capillary and venous endothelial cells but not in arterial cells, revealing stage-dependent responses and a protective mechanism against arterial damage.