Context-dependent response of endothelial cells to PIK3CA mutation
Helena Sabata, Ariadna Roca-Coll, Jose A. Dengra, Leonor Gouveia, Ane Martinez‐Larrinaga, Alberto Collado-Remacha, Sandra D. Castillo, Elena Castillo, Nathalie Tisch, Macarena De Andrés-Laguillo, Svanhild Nornes, Judith Llena, Pilar Villacampa, Bart Vanhaesebroeck, Maria Pilar Alcolea, , Mariona Graupera
This study shows that PIK3CAH1047R mutation causes clonal expansion in capillary and venous endothelial cells but not in arterial cells, revealing stage-dependent responses and a protective mechanism against arterial damage.
bioRxiv · Feb 25, 2025 · PreprintDevelopmental Biology