Author

Ana Angulo‐Urarte

Josep Carreras Leukaemia Research InstituteORCID 0000-0002-8024-814XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2

Frequent Co-Authors

Eulàlia BaselgaiD· 2 shared Helena SabataiD· 2 shared Mariona GrauperaiD· 2 shared Sandra D. CastilloiD· 2 shared Susana López Fernández· 2 shared Alberto Collado-Remacha· 1 shared Ane Martinez‐LarrinagaiD· 1 shared Ariadna Roca-ColliD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersDevelopmental Biology

Eulàlia BaselgaORCID

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2 papers

Recent·Most cited

Context-dependent response of endothelial cells to PIK3CA mutation

Helena Sabata, Ariadna Roca-Coll, Jose A. Dengra, Leonor Gouveia, Ane Martinez‐Larrinaga, Alberto Collado-Remacha, Sandra D. Castillo, Elena Castillo, Nathalie Tisch, Macarena De Andrés-Laguillo, Svanhild Nornes, Judith Llena, Pilar Villacampa, Bart Vanhaesebroeck, Maria Pilar Alcolea, , Mariona Graupera

This study shows that PIK3CAH1047R mutation causes clonal expansion in capillary and venous endothelial cells but not in arterial cells, revealing stage-dependent responses and a protective mechanism against arterial damage.

bioRxiv · Feb 25, 2025 · PreprintDevelopmental Biology

Low dose AKT inhibitor miransertib cures PI3K-related vascular malformations in preclinical models of human disease

Piotr Kobialka, Helena Sabata, Odena Vilalta, Ana Angulo‐Urarte, Laia Muixí, Jasmina Zanoncello, Oscar Muñoz‐Aznar, Nagore Gené Olaciregui, Cinzia Emilia Lavarino, Verónica Celis, Carlota Rovira, Susana López Fernández, Eulàlia Baselga, Jaume Mora, Sandra D. Castillo, Mariona Graupera

The paper develops a preclinical model of PI3K-driven vascular malformations and shows that low-dose AKT inhibitor miransertib prevents and regresses these malformations in mice and human endothelial cells.

bioRxiv · Jul 16, 2021 · PreprintMolecular Biology