Author

Chen Khuan Wong

Memorial Sloan Kettering Cancer CenterORCID 0000-0001-9811-3334Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Cancer Biology· 2 Cell Biology· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

Yu CheniD· 4 shared Dan LiiD· 2 shared Ping ChiiD· 2 shared Wenfei Kang· 2 shared Alexander Martinez‐FundichelyiD· 1 shared Ana Molina· 1 shared Andrea SboneriD· 1 shared Anisha B. Tehim· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersCancer Biology

Yu ChenORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 9, 2026

MYC drives endothelial transformation and dedifferentiation in angiosarcoma

Chen Khuan Wong, Dan Li, Tomer Itkin…·Yu Chen

This study shows MYC drives endothelial transformation and dedifferentiation in angiosarcoma by promoting lineage plasticity and cell growth.

DOI 10.64898/2026.10.07.757149

𝕏 PostBluesky

Cancer BiologybioRxivPreprintMay 8, 2026

Dependencies in heterogeneous, lineage plastic patient-derived prostate cancer organoids revealed through integrated single-cell multiomics and CRISPR screening

Samir Zaidi, Maren Büttner, Weiran Feng…·Charles L. Sawyers

The paper integrates single-cell multiomics and CRISPR screening in prostate cancer organoids to reveal lineage-specific dependencies and heterogeneity effects on gene essentiality.

1 citation

𝕏 PostBluesky

Cell BiologybioRxivPreprintFeb 16, 2026

Cell-Autonomous AR Dependence in Luminal Prostatic Epithelium Governs Survival and Lineage Plasticity

Dan Li, Naitao Wang, Wangxin Guo…·Yu Chen

This study shows that luminal prostatic epithelial cells depend on AR signaling for survival and differentiation, and their loss triggers compensatory pathways and lineage plasticity.

DOI 10.64898/2026.02.13.705807

mousebulk RNA-seq

𝕏 PostBluesky

Genetic & Genomic MedicinemedRxivPreprintJul 1, 2025

Genomic alterations in the YAP/TAZ pathway are associated with stem cell-like castration-resistant prostate cancer

Marjorie L. Roskes, Alexander Martinez‐Fundichely, Sandra M. Cohen…·Ekta Khurana

The paper identifies genomic alterations in the YAP/TAZ pathway associated with stem cell-like castration-resistant prostate cancer using transcriptomic and whole-genome sequencing data.

DOI 10.1101/2025.07.01.25330467

humanbulk RNA-seq

𝕏 PostBluesky