Author

Charles H. Large

Stevenage Bioscience CatalystORCID 0000-0001-9814-7737Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:electronic health records· 1 Organism:rat· 1

Frequent Co-Authors

Caitlin Davies· 1 shared Carl W. StevensoniD· 1 shared Chaitra SathyaprakashiD· 1 shared Christine StubbendorffiD· 1 shared Cristina Scutariu· 1 shared Ed Hale· 1 shared Giuseppe S. Alvaro· 1 shared Harriet L. L. DayiD· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperNeuroscience

Caitlin Davies

Mutual co-authors in cluster

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3 papers

Recent·Most cited

NeuroscienceProgress in Neuro-Psychopharmacology and Biological PsychiatryPeer-reviewedJul 12, 2023

Regulation of auditory fear discrimination by the novel Kv3 voltage-gated potassium channel modulator AUT00206

Christine Stubbendorff, Ed Hale, Harriet L. L. Day…·Carl W. Stevenson

This study investigates the effects of the Kv3.1/3.2 modulator AUT00206 on fear discrimination in rats, showing response-specific modulation of generalization and expression.

7 citations

ratexperimental assay

𝕏 PostBluesky

NeuroscienceeNeuroPeer-reviewedJan 1, 2022

Kv3 channels contribute to the excitability of sub-populations of spinal cord neurons in lamina VII

Pierce N. Mullen, Nadia Pilati, Charles H. Large…·Susan A. Deuchars

The paper identifies four neuronal types in spinal cord lamina VII, showing Kv3 channels are critical for fast firing in interneurons and synaptic inhibition of parasympathetic preganglionic neurons.

DOI 10.1523/eneuro.0510-21.2021

mouseelectronic health records

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NeuroscienceBrain and Neuroscience AdvancesPeer-reviewedJan 1, 2022

Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model of Alzheimers disease

Jie Yeap, Chaitra Sathyaprakash, Jamie Toombs…·Tara L. Spires‐Jones

This study shows reducing Kv3.4 levels in a mouse model of Alzheimer's disease reduces synapse loss and changes in spine morphology.

16 citations

mouseexperimental assay

𝕏 PostBluesky