Adrián Salas-Bastos

This study shows that chronic FGF23 elevation causes kidney inflammation via sustained ERK signaling, which is reduced by cFGF23 gene therapy.

The paper uses single-cell RNA sequencing to study hippocampal development in DOT1L-mutant mice, identifying distinct neural stem cell populations and their developmental trajectories, revealing DOT1L's role in cell state preservation and hippocampal maturation.

This study evaluates deep generative models for scRNA-seq data, finding that they can support experimental design but have limitations in capturing cell type proportions and bimodal gene distributions.