Josip S. Herman

Gene expression noise dynamics unveil functional heterogeneity of ageing hematopoietic stem cells

The paper develops VarID2 to quantify biological noise in single-cell RNA-seq data, revealing noise dynamics in hematopoietic stem cells during differentiation and ageing.

Single-cell transcriptomic resolution of stem cells and their developmental trajectories in the hippocampus reveals epigenetic control of cell state perseverance

The paper uses single-cell RNA sequencing to study hippocampal development in DOT1L-mutant mice, identifying distinct neural stem cell populations and their developmental trajectories, revealing DOT1L's role in cell state preservation and hippocampal maturation.

A Human Liver Cell Atlas: Revealing Cell Type Heterogeneity and Adult Liver Progenitors by Single-Cell RNA-sequencing

This paper constructs a human liver cell atlas using single-cell RNA-sequencing to identify new cell subtypes and progenitors, and applies it to study liver disease and engraftment.

Deciphering the Regulatory Landscape of γδ T Cell Development by Single-Cell RNA-Sequencing

This study uses single-cell RNA-sequencing to uncover the developmental trajectory of γδ T cells, identifying c-MAF as a key regulator of IL-17-producing γδ T cell differentiation.

FateID infers cell fate bias in multipotent progenitors from single-cell RNA-seq data

FateID quantifies cell fate bias in multipotent progenitors using single-cell RNA-seq data, revealing a common progenitor population for B cells and plasmacytoid dendritic cells.