William Nasser

The paper introduces GRATIOSA, a tool for integrated spatial analysis of genome-scale data, and applies it to study topoisomerase recruitment in E. coli.

This study shows that three Fis proteins in L. pneumophila regulate virulence genes through distinct and cooperative mechanisms, rather than as redundant backups.

The paper investigates gene responses to topoisomerase I inhibition in Dickeya dadantii, finding distinct gene expression patterns compared to gyrase inhibition and highlighting the complexity of supercoiling-sensitive regulation.

This study develops a thermodynamic model to quantify how spacer length in bacterial promoters affects supercoiling sensitivity, validated through in vitro and in vivo experiments and whole-genome analysis in E. coli.

The paper develops a regulatory model of carbon catabolite repression in Dickeya dadantii, showing how glucose and pectin metabolism control pel gene expression during virulence.

This paper sequenced the genome of Dickeya aquatica, showing its pathogenic potential and revealing evolutionary dynamics in Dickeya species.