Christophe Ginévra

The paper develops a bioinformatic pipeline using 23S-5S rRNA sequencing to identify Legionella species in culture-negative PCR-positive samples, successfully assigning species in 60% of cases and revealing high diversity.

The paper shows that incorporating allelic variability improves proteome coverage and identification confidence in DIA proteomics using Legionella pneumophila isolates.

This study compares immune gene expression in ICU and non-ICU Legionnaires' disease patients after LPS stimulation, finding more pronounced functional impairments in ICU patients.

This study shows that mobile genetic elements in bacteria generate antibiotic persistence traits through heterogeneous chromosomal excision, enhancing survival under antibiotic treatment.

The paper quantifies transformation rates in bacterial pathogens and links them to intragenomic conflicts with mobile genetic elements, showing similar evolutionary trends across species.

This study shows that three Fis proteins in L. pneumophila regulate virulence genes through distinct and cooperative mechanisms, rather than as redundant backups.

This study evaluates four NGS methods for SARS-CoV-2 whole-genome sequencing, finding that amplicon-based methods are most sensitive for low viral loads while mNGS and RVOP produce the most complete genomes for mid viral loads.