Sam Meyer

This study shows that chromosomal topological domains in E. coli repress transcription, reduce orientation effects, and modulate gene coupling through supercoiling changes.

This paper develops a computational model to quantify how DNA supercoiling and topoisomerases regulate bacterial transcription, showing distinct roles for topoisomerase I and gyrase in gene expression.

This study shows that DNA supercoiling-mediated interactions between genes can shape genome organization and regulate gene expression through evolutionary adaptation.

The paper introduces GRATIOSA, a tool for integrated spatial analysis of genome-scale data, and applies it to study topoisomerase recruitment in E. coli.

The paper investigates gene responses to topoisomerase I inhibition in Dickeya dadantii, finding distinct gene expression patterns compared to gyrase inhibition and highlighting the complexity of supercoiling-sensitive regulation.

This study develops a thermodynamic model to quantify how spacer length in bacterial promoters affects supercoiling sensitivity, validated through in vitro and in vivo experiments and whole-genome analysis in E. coli.

The paper develops a regulatory model of carbon catabolite repression in Dickeya dadantii, showing how glucose and pectin metabolism control pel gene expression during virulence.