A long-lived pool of PINK1 imparts a molecular memory of depolarisation-induced activity.
Liam Pollock, Ioanna Ch. Georgiou, Emma V. Rusilowicz-Jones, Michael J. Clague, Sylvie Urbé
The paper shows that PINK1 accumulates on mitochondria under depolarisation, remains active, and can precondition subsequent PINK1 activation.
Science Advances · Feb 28, 2025Peer-reviewedCell Biology