Ioanna Ch. Georgiou

The paper shows that mitochondrial depolarisation inhibits PPTC7 import, leading to its degradation and the loss of NIX and BNIP3, thereby switching mitophagy pathways.

The paper shows that PINK1 accumulates on mitochondria under depolarisation, remains active, and can precondition subsequent PINK1 activation.

This study shows UBR5 interacts with the HH pathway to regulate skeletal homeostasis and identifies potential targets for biomedical applications.