Michael J. Clague

The paper shows that mitochondrial depolarisation inhibits PPTC7 import, leading to its degradation and the loss of NIX and BNIP3, thereby switching mitophagy pathways.

This study develops refined USP25/28 inhibitors that selectively target c-MYC driven squamous lung cancer cells with reduced off-target effects and toxicity.

The paper shows that HRS dephosphorylation at ER:MVE contacts promotes efficient ILV formation during MVE sorting.

This paper demonstrates that targeted recruitment of USP15 stabilizes CTLA4 at the cell surface by redirecting it from lysosomal degradation, providing a foundation for ENTAC design.

The paper shows that PINK1 accumulates on mitochondria under depolarisation, remains active, and can precondition subsequent PINK1 activation.

The paper investigates CTLA4 turnover, showing ubiquitylation at K203 and K213 drives lysosomal degradation, with USP8 and HD-PTP modulating this process through distinct mechanisms.