Anna L. Duncan

Molecular insights into ATP synthase c-ring accumulation in BMP-deficient lysosomes in Batten disease

This study investigates how BMP deficiency in Batten disease leads to lysosomal accumulation of ATP synthase c-rings through molecular simulations showing BMP's preferential interaction with the c-ring.

Mechanistic Insights into Na+-dependent HCO3- Transport by NBCn2 (SLC4A10)

This study investigates the mechanism of Na+-dependent HCO3- transport by NBCn2 using structure prediction and simulations, revealing sequential ion binding and conformational changes.

Structural characterisation of a spontaneous site 1 opening event in the insulin receptor

The paper reports a spontaneous structural transition in the insulin receptor during molecular dynamics simulation, revealing a conformation compatible with hybrid insulin binding sites.

The Role of Cholesterol in M2 Clustering and Viral Budding Explained

This paper uses molecular dynamics simulations to show that cholesterol stabilizes M2 channel clusters, enhancing membrane curvature and promoting viral budding.