Author

Lasse Messell Desdorf

Aarhus UniversityORCID 0009-0004-3290-3869Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Amanda Dyrholm StangeiD· 2 shared Helle Hasager DamkieriD· 2 shared Jeppe PrætoriusiD· 2 shared Anna L. DuncaniD· 1 shared Antje K. Huebner· 1 shared Birgit SchiøttiD· 1 shared Cody W. GearyiD· 1 shared Ebbe Sloth AnderseniD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersBiophysics

Amanda Dyrholm StangeORCID

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Author profile →

3 papers

Recent·Most cited

Ncbe is the main basolateral Na+ loading mechanism of the choroid plexus epithelium

Lasse Messell Desdorf, Sigurd Kassow Morsby, Laura Øllegaard Johnsen, Nicoline Stærke Jensen, Antje K. Huebner, Helle Hasager Damkier, Jeppe Prætorius

This study identifies Ncbe as the primary Na+ loading mechanism at the basolateral membrane of choroid plexus epithelial cells, supporting its role in CSF secretion.

bioRxiv · Aug 26, 2026 · PreprintPhysiology

Mechanistic Insights into Na+-dependent HCO3- Transport by NBCn2 (SLC4A10)

Lasse Messell Desdorf, Amanda Dyrholm Stange, Helle Hasager Damkier, Birgit Schiøtt, Jeppe Prætorius, Anna L. Duncan

This study investigates the mechanism of Na+-dependent HCO3- transport by NBCn2 using structure prediction and simulations, revealing sequential ion binding and conformational changes.

Structure · Aug 25, 2026Peer-reviewedBiophysics

Fluorinated RNA origami enables serum-stable nanodevices for sensing and targeting

Emil L. Kristoffersen, Nikolaj Holck Zwergius, Néstor Sampedro Vallina, Amanda Dyrholm Stange, Lasse Messell Desdorf, Sofie Thomsen, Victoria Birkedal, Nicolas Glück, Laia Civit, Cody W. Geary, Jørgen Kjems, Julián Valero, Ebbe Sloth Andersen

This paper introduces FY-RNA origami structures that are serum-stable and capable of molecular sensing and targeting, revealing structural insights through cryo-EM and simulations.

bioRxiv · Mar 4, 2026 · PreprintBiochemistry