Mark S.P. Sansom

This study determines the structure of TbAQP2 bound to drugs and glycerol, revealing how mutations in the channel lead to drug resistance in Trypanosoma brucei.

This paper uses molecular dynamics simulations to show that cholesterol stabilizes M2 channel clusters, enhancing membrane curvature and promoting viral budding.

The paper reports cryo-EM and crystal structures of GABAA receptors with ligands, revealing the molecular basis of BZD modulation.